AN ANTIBIOTIC AFTER 25 LONG YEARS- A COMEBACK FINALLY !!!
January 2015 gave rise to a new antibiotic discovered after a long wait of 25 years (the last antibiotic was discovered in 1987). This discovery can be considered as a 'NEW YEAR GIFT TO MANKIND' because the uniqueness of antibiotic 'TEIXOBACTIN' lies in the fact that it is active against Gram positive bacteria which has acquired resistance over other antibiotics.
There was a fear in the minds of people that antibiotic will no longer be beneficial in coming years due to the spread of resistance over antibiotics in the recent years e.g. Multi-Drug resistant- Tuberculosis (MDR-TB). Thus the discovery comes as a ray of hope in treating resistant bacterial as well as other microbial species.
Teixobactin was isolated from the previously uncultured soil bacteria by iChip (isolation chip) technology. It is a cell wall biosynthesis inhibitor by binding to the lipid precursors (especially lipid II) of peptidoglycan. The blocking of lipid precursors results in the inhibition of peptidoglycan which in turn results in the cell lysis of the concerned bacteria.
Teixobactin is effective in vitro against most of the Gram positive bacterial species like Mycobacterium tuberculosis, Staphylococcus aureus, Bacillus anthrasis, Clostridium difficile, enterococci and in in vivo it is effective against methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae. The in vivo activity was, however, tested on mice and still clinical trials are yet to be carried on human beings.
TEIXOBACTIN IS NOT PROVED TO BE EFFECTIVE AGAINST GRAM- NEGATIVE BACTERIA.
One of the co-discover has stated that Teixobactin will hit the market only in next 5-6 years. However, pharmaceutical companies are reluctant to invest in the manufacture, development and marketing of new antibiotics due to the fear that due to use prolonged use, it may acquire resistance.
Teixobactin is discovered in Northeastern University,Boston with Prof. Kim Lewis being the lead research scientist.
Since, micro-organisms are getting stronger and stronger by the day due to the resistance, we need to strictly follow the proper instructions by our family doctor, pharmacist or any healthcare expert regarding the proper course and administration of antibiotics.
Self-medication should be avoided, the whole course of antibiotic should be completed even we feel better by the 2nd of 3rd day of medication regime (considering it as a 5-day regime). If any past "antibiotic-resistant" experience has occurred then that should be reported to the doctor beforehand.
Lets hope for a better future with more effective antibiotics being discovered in the coming future to save the mankind from dare consequences of antibiotic-resistance of microbes..!!!
STRUCTURE OF TEIXOBACTIN
-DARWIN
January 2015 gave rise to a new antibiotic discovered after a long wait of 25 years (the last antibiotic was discovered in 1987). This discovery can be considered as a 'NEW YEAR GIFT TO MANKIND' because the uniqueness of antibiotic 'TEIXOBACTIN' lies in the fact that it is active against Gram positive bacteria which has acquired resistance over other antibiotics.
There was a fear in the minds of people that antibiotic will no longer be beneficial in coming years due to the spread of resistance over antibiotics in the recent years e.g. Multi-Drug resistant- Tuberculosis (MDR-TB). Thus the discovery comes as a ray of hope in treating resistant bacterial as well as other microbial species.
Teixobactin was isolated from the previously uncultured soil bacteria by iChip (isolation chip) technology. It is a cell wall biosynthesis inhibitor by binding to the lipid precursors (especially lipid II) of peptidoglycan. The blocking of lipid precursors results in the inhibition of peptidoglycan which in turn results in the cell lysis of the concerned bacteria.
Teixobactin is effective in vitro against most of the Gram positive bacterial species like Mycobacterium tuberculosis, Staphylococcus aureus, Bacillus anthrasis, Clostridium difficile, enterococci and in in vivo it is effective against methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae. The in vivo activity was, however, tested on mice and still clinical trials are yet to be carried on human beings.
TEIXOBACTIN IS NOT PROVED TO BE EFFECTIVE AGAINST GRAM- NEGATIVE BACTERIA.
One of the co-discover has stated that Teixobactin will hit the market only in next 5-6 years. However, pharmaceutical companies are reluctant to invest in the manufacture, development and marketing of new antibiotics due to the fear that due to use prolonged use, it may acquire resistance.
Teixobactin is discovered in Northeastern University,Boston with Prof. Kim Lewis being the lead research scientist.
Since, micro-organisms are getting stronger and stronger by the day due to the resistance, we need to strictly follow the proper instructions by our family doctor, pharmacist or any healthcare expert regarding the proper course and administration of antibiotics.
Self-medication should be avoided, the whole course of antibiotic should be completed even we feel better by the 2nd of 3rd day of medication regime (considering it as a 5-day regime). If any past "antibiotic-resistant" experience has occurred then that should be reported to the doctor beforehand.
Lets hope for a better future with more effective antibiotics being discovered in the coming future to save the mankind from dare consequences of antibiotic-resistance of microbes..!!!
STRUCTURE OF TEIXOBACTIN
-DARWIN
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