JANUARY- FEBRUARY 2015 US-FDA APPROVED DRUGS

                                JANUARY- FEBRUARY 2015 US-FDA APPROVED DRUGS

A. JANUARY 2015 US-FDA APPROVED DRUGS

1. TRADE (BRAND) NAME- Prestalia
ACTIVE PHARMACEUTICAL INGREDIENT- Perindopril arginine and amlodipine besylate
COMPANY- Sympelmed Pharmaceuticals
USE- This combination drug formulation is used for the treatment of hypertension. Perindopril is a long acting ACE-inhibitor while amlodipine is long acting dihydropyridine calcium channel blocker.

                                                                     PERINDOPRIL

                                                         

                                                                   
                                                                      AMLODIPINE

2. TRADE (BRAND) NAME- Savaysa
ACTIVE PHARMACEUTICAL INGREDIENT- Edoxaban
COMPANY- Daiichi Sankyo
USE- Edoxaban is an anti-coagulant and is an inhibitor of factor Xa. It prevents the risk of stroke and embolism due to atrial fibrillation, and for the treatment of pulmonary embolism and deep vein thrombosis.

                                                                    EDOXABAN

3. TRADE (BRAND) NAME- Cosentyx
ACTIVE PHARMACEUTICAL INGREDIENT-  Secukinumab
COMPANY- Novartis
USE- It is a human antibody indicated for the treatment for plaque psoriasis (one of the 5 types of psoriasis and also most common type). Plaque psoriasis manifests in the form of red and white scaly patches on the top layer of skin and is characterized usually by intense itching.

4. TRADE (BRAND) NAME- Natpara
ACTIVE PHARMACEUTICAL INGREDIENT-  Parathyroid hormone
COMPANY- NPS Pharmaceuticals
USE- This hormone is used for controlling hypocalcemia in patients with hypoparathyroidism by increasing the calcium ion concentration in blood by acting on parathyroid hormone receptor 1 & 2.

5. TRADE (BRAND) NAME- Evotaz
ACTIVE PHARMACEUTICAL INGREDIENT- Atazanavir and Cobicistat
COMPANY- Bristol-Myers Squibb
USE- Atazanavir is an antiretroviral drug of the protease inhibitor class which is used for the treatment of HIV-1 infection
Cobicistat is a potent CYP450 enzyme class (CYP3A4 sub-type) inhibitor thus increasing the bio availability of other HIV-1 medications including atazanavir.

                                                                         ATAZANAVIR

                                                                         COBICISTAT
                                                               
 6. TRADE (BRAND) NAME- Prezcobix
ACTIVE PHARMACEUTICAL INGREDIENT- Darunavir and Cobicistat
COMPANY- Janssen
USE- Darunavir belongs to protease inhibitor class of drugs used for treatment of HIV-1 infection. The role of Cobicistat is mentioned above.

                                                          DARUNAVIR

7. TRADE (BRAND) NAME- Duopa enteral suspension
ACTIVE PHARMACEUTICAL INGREDIENT- Carbidopa and Levodopa
COMPANY- Abbvie
USE- Levodopa or L-DOPA increases the concentration of dopamine in the brain of the patients suffering from Parkinson's disease (PD).
Carbidopa is an aromatic L-amino acid decarboxylase inhibitor which prevents the peripheral metabolism of L-DOPA and thus increases the levels of L-DOPA crossing the blood brain barrier (BBB) for central nervous system (CNS) effect.
This enteral suspension is basically indicated for the treatment of motor fluctuations associated with advanced PD.

                                                                LEVODOPA

                                                               CARBIDOPA

8. TRADE (BRAND) NAME- Rytary extended release capsules
ACTIVE PHARMACEUTICAL INGREDIENT- Carbidopa and Levodopa
COMPANY- Impax Labs
USE- Treatment of PD.

9. TRADE (BRAND) NAME- Bexsero
ACTIVE PHARMACEUTICAL INGREDIENT- Meningococcal Group B vaccine
COMPANY- Novartis
USE- It is used for the treatment of invasive meningococcal disease caused by serogroup B of bacterium Neisseria meningitidis.


B. FEBRUARY 2015 US-FDA APPROVED DRUGS

1. TRADE (BRAND) NAME- Ibrance
ACTIVE PHARMACEUTICAL INGREDIENT- Palbociclib
COMPANY- Pfizer
USE- Palbociclib is a selective inhibitor cyclin- dependent kinases CDK4 and CDK6. Cyclin-dependent kinases are a group of enzymes belonging to protease family. They are involved in cell regulation activities like mRNA processing, transcription etc. Mutation of CDK4 and over-expression of CDK6 are related with the cause of cancer.
This drug in combination with letrozole (non-steroidal aromatase inhibitor for the treatment of hormonally responsive breast cancer) is used in treatment of patients with estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer.

                                           
                                                            PALBOCICLIB

2. TRADE (BRAND) NAME- Lenvima
ACTIVE PHARMACEUTICAL INGREDIENT- Lenvatinib
COMPANY- Eisai
USE- Lenvatinib is a multi-kinase growth inhibitor especially inhibiting vascular endothelial growth factor receptor kinases 2 & 3 (VEGFR Kinases 2 & 3).
It is used fro the treatment of thyroid cancer.

LENVATINIB

                                                                                             -DARWIN