JULY-2014 US-FDA APPROVED DRUGS

1.TRADE (BRAND) NAME-Targiniq ER 

ACTIVE PHARMACEUTICAL INGREDIENTS-Oxycodone hydrochloride + Naloxone hydrochloride extended-release tablets

COMPANY-Purdue Pharma

USE-For the management of severe chronic pain

Oxycodone is a semi-synthetic opioid drug which is indicated for the treatment of acute and chronic pain.It is sythesized from poppy-derived thebaine and acts on the K-2b opioid receptors and thus relieves mild to moderate pain.

Naloxone on the other hand is pure opioid antagonists which is co-administered probably because to revert the overdosage,intolerability and to conteract the other side-effects of oxycodone.

IUPAC Name(Oxycodone hydrochloride)-(5R,9R,13S,14S)-4,5α-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one

IUPAC Name(Naloxone hydrochloride)-(1S,5R,13R,17S)- 10,17-dihydroxy- 4-(prop-2-en-1-yl)- 12-oxa- 4-azapentacyclo [9.6.1.0^1,13.0^5,17.0^7,18] octadeca- 7(18),8,10-trien- 14-one

2.TRADE (BRAND) NAME-Kerydin 

ACTIVE PHARMACEUTICAL INGREDIENT-Tavaborole

COMPANY-Anacor

USE-For the treatment of onychomycosis of the toenails,

Tavaborole is a topical antifungal drug which inhibits the enzyme-leucyl transfer RNA synthetase which in turn stops the protein synthesis in the fungi.

The structure is unique in the way that it has boron atom in the ring.

IUPAC Name-5-Fluoro-2,1-benzoxaborol-1(3H)-ol

3.TRADE(BRAND) NAME-Zydelig 

ACTIVE PHARMACEUTICAL INGREDIENT-Idelalisib

COMPANY- Gilead 

USE-For the treatment of relapsed CLL(Chronic Lymphocytic Leukemia), follicular B-cell NHL(Non-Hodgkin's Lymphoma) and SLL(Small Lymphocytic Lymphoma)

Idelalisib is a phosphoinositide-3-kinase inhibitor and more specifically inhibits the delta isoform of the enzyme.It is a second line drug in patients whose CLL,B-cell

NHL and SLL has relapsed.Generally used in combination with Rituximab.

IUPAC Name-5-Fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]-4(3H)-quinazolinone

4.TRADE (BRAND) NAME-Ruconest 

ACTIVE PHARMACEUTICAL INGREDIENT-C1 esterase inhibitor [recombinant]

COMPANY-Pharming Group

USE-For the treatment of hereditary angioedema


5.TRADE(BRAND) NAME-Beleodaq 

ACTIVE PHARMACEUTICAL INGREDIENT-Belinostat

COMPANY-Spectrum Pharmaceuticals

USE- For the treatment of relapsed or refractory peripheral T-cell lymphoma

Belinostat is a histone deacetylase inhibitor used for the treatment of haematological malignancies and solid tumours.It has been granted the orphan drug (A pharmacutical

agent which is developed and used for a particular rare medical condition.)

and fast track recognition by FDA( A designation by US-FDA for the development and review of drugs developed for a life-threatening and serious medical condition.The

purpose is to bring the new drugs earlier in the market.)

IUPAC Name-(2E)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide

                                                                                                                     -Darwin